Description
LGD-4033 is the most anabolically potent SARM available — a Selective Androgen Receptor Modulator engineered for maximum lean muscle growth, dramatic strength gains, and superior body recomposition with minimal androgenic side effects. LGD-4033 (also known as Ligandrol or VK5211) demonstrated ~1.3kg lean mass gain in just 21 days at 1mg/day in Phase 1 human clinical trials, making it the most proven SARM for lean bulking in research to date. ✔️ Purity ≥99% — Third-party HPLC tested — Made in the USA.
What Is LGD-4033 (Ligandrol)?
LGD-4033 is a non-steroidal SARM that binds with high affinity to androgen receptors in skeletal muscle and bone tissue while avoiding androgenic activity in other tissues. Originally developed by Ligand Pharmaceuticals and later advanced by Viking Therapeutics, LGD-4033 Ligandrol has more Phase 1 human trial data than almost any other SARM — with consistent evidence of significant lean mass gains, improved strength, and a manageable safety profile. Comparing SARMs to peptides for your goals? Read our full Peptides vs SARMs guide.
LGD-4033 Benefits
- Superior lean muscle gains: LGD-4033 produces the highest muscle growth output of any widely-researched SARM — measurable lean mass gains within 4–6 weeks of use
- Dramatic strength increases: LGD-4033 users consistently report significant strength improvements within the first 2–3 weeks
- Lean bulking without fat gain: LGD-4033 promotes lean tissue growth without significant water retention or fat accumulation
- Muscle preservation during caloric deficit: LGD-4033 protects lean mass even under aggressive caloric restriction — stack with AOD-9604 or Tirzepatide for combined fat loss + muscle retention
- Bone density support: LGD-4033 strengthens bone mineral density through androgen receptor activation in bone tissue
- Accelerated recovery: Faster muscle repair between sessions, supporting higher training volume and frequency
LGD-4033 Specifications
| Attribute | Details |
|---|---|
| Product Name | LGD-4033 (Ligandrol / VK5211) |
| Category | SARMs |
| Available Forms | Dry-fill capsules (10mg x 60), Liquid (10mg/mL x 30mL), Oil (50mg/mL x 10mL) |
| Purity | ≥99% (Third-party HPLC tested) |
| Typical Research Dose | 5–10mg/day |
| Cycle Length | 8–12 weeks |
| Best For | Lean bulking, muscle growth, strength, body recomposition |
| Origin | Made in the USA |
| Use | Research purposes only |
How to Stack LGD-4033
- Lean bulking stack: LGD-4033 + MK-2866 (Ostarine) for amplified lean muscle with joint support — see our Lean Muscle SARMs Stack
- Maximum bulk stack: LGD-4033 + MK-677 (Ibutamoren) for lean mass + GH-driven recovery — see our SARMs Bulking Cycle
- Recomposition: LGD-4033 + GW-501516 (Cardarine) for simultaneous muscle gain and fat oxidation
- Peptide + SARM stack: LGD-4033 + Ipamorelin + CJC-1295 for lean mass + GH restoration + recovery
- Cutting: LGD-4033 (lower dose) + AOD-9604 for muscle preservation + direct fat mobilisation
LGD-4033 vs Other SARMs
LGD-4033 delivers the highest anabolic output of commonly researched SARMs — making it the first choice for lean bulking. Compared to MK-2866 (Ostarine), LGD-4033 delivers more muscle mass with slightly higher testosterone suppression. Compared to RAD-140 (Testolone), LGD-4033 is better for pure mass accumulation. For the full body composition comparison, read our Peptides vs SARMs guide.
Post-Cycle Therapy After LGD-4033
LGD-4033 is one of the more suppressive SARMs and PCT is strongly recommended after a standard 8–12 week cycle. Use Nolvadex (Tamoxifen) or Enclomiphene to accelerate recovery. Adding Ipamorelin post-cycle supports GH recovery and preserves body composition during the hormonal transition.
LGD-4033 FAQ
What makes LGD-4033 different from other SARMs?
LGD-4033 has the highest anabolic potency of commonly researched SARMs, with Phase 1 human trials showing ~1.3kg lean mass gain in 21 days at 1mg/day. Compare head-to-head with MK-2866 and RAD-140.
Does LGD-4033 require PCT?
Yes — LGD-4033 is suppressive. PCT with Nolvadex or Enclomiphene is recommended after every cycle. Testosterone typically recovers within 4–8 weeks.
Can I stack LGD-4033 with peptides?
Yes — LGD-4033 and peptides work through completely different mechanisms. Ipamorelin + LGD-4033 is a highly effective lean mass + recovery stack. Read our Peptides vs SARMs guide for more.
⚠️ Research Use Only: LGD-4033 (Ligandrol) is sold strictly for laboratory and scientific research purposes. It is not intended for human consumption or in-vivo use. Not evaluated or approved by the FDA.
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